Definition

Cytokines are signaling proteins released by immune cells that mediate and regulate immunity, inflammation, and cell-to-cell communication. Pro-inflammatory cytokines (IL-1, IL-6, TNF-alpha) promote inflammation, while anti-inflammatory cytokines (IL-10, IL-4) resolve it. Cytokine imbalances drive autoimmune and chronic inflammatory diseases.

Why It Matters

Chronic elevation of pro-inflammatory cytokines creates a state of low-grade inflammation that damages tissues and drives chronic disease. Balancing cytokine production through diet, lifestyle, stress management, and targeted therapies is essential for resolving chronic inflammation and autoimmune conditions.

Related Conditions

Autoimmunity Chronic Inflammation Rheumatoid Arthritis Inflammatory Bowel Disease

Related Modalities

Functional Lab Testing Clinical Nutrition Botanical Medicine Lifestyle Medicine

Frequently Asked Questions

Common causes include chronic infections, gut dysbiosis and leaky gut, obesity, poor diet high in sugar and processed foods, chronic stress, sleep deprivation, sedentary lifestyle, toxin exposure, and autoimmune conditions. Addressing root causes reduces cytokine-driven inflammation.

Effective strategies include anti-inflammatory diet rich in omega-3s and polyphenols, regular exercise, stress management, adequate sleep, weight loss if needed, probiotics for gut health, omega-3 supplements, curcumin, resveratrol, and immune-modulating herbs like reishi mushroom.