Definition

Methylation is a biochemical process involving the transfer of methyl groups (one carbon and three hydrogen atoms) to DNA, proteins, and other molecules. Methylation regulates gene expression, neurotransmitter production, detoxification, hormone metabolism, and cellular repair. Genetic variations (like MTHFR mutations) can impair methylation.

Why It Matters

Impaired methylation contributes to depression, anxiety, cardiovascular disease, birth defects, cancer, neurodegenerative disease, and detoxification issues. Supporting methylation with methylated B vitamins (methylfolate, methylcobalamin), betaine, and choline optimizes these critical processes and reduces disease risk.

Related Conditions

Depression Anxiety Cardiovascular Disease Infertility Support Autoimmunity

Related Modalities

Functional Lab Testing Nutraceuticals Clinical Nutrition

Frequently Asked Questions

MTHFR is a gene that provides instructions for an enzyme critical to folate metabolism and methylation. MTHFR mutations (especially C677T and A1298C) reduce enzyme activity, impairing methylation. People with MTHFR mutations benefit from methylated B vitamins (methylfolate instead of folic acid).

Support methylation with methylated B vitamins (methylfolate, methylcobalamin, P-5-P), choline, betaine (trimethylglycine), adequate protein, leafy greens, beets, managing stress, limiting alcohol, optimizing gut health, and testing for MTHFR mutations to personalize supplementation.