SIBO (Small Intestinal Bacterial Overgrowth)

In Brief

Dr. Sanika Kshirsagar at Soma Naturopathic in Kirkland, WA works up SIBO with breath testing, treats the overgrowth with antimicrobial herbs or referral for antibiotics, and then — the step most often skipped — addresses the motility problem, low stomach acid, or structural issue that allowed the overgrowth in the first place, because SIBO that is treated without addressing its cause reliably comes back.

SIBO is an excess of bacteria in the small intestine, where bacterial counts should be low. Those bacteria ferment carbohydrate before it can be absorbed, producing hydrogen, methane or hydrogen sulphide gas. The result is bloating that worsens through the day, distension that can be dramatic, and altered bowel habit. SIBO is strongly associated with IBS — a substantial share of people diagnosed with IBS have demonstrable overgrowth — and it is frequently the missing explanation for someone who has been told their extensive GI workup was normal.

Symptoms

  • Bloating and visible abdominal distension that worsens as the day goes on
  • Excessive gas, belching, and abdominal discomfort after meals
  • Diarrhoea, constipation, or an alternating pattern between the two
  • Feeling full very quickly, nausea, or reflux
  • Fatigue and brain fog, often disproportionate to the gut symptoms
  • Nutrient deficiencies — particularly iron and vitamin B12 — from impaired absorption
  • Reacting badly to foods that are otherwise healthy, especially fibre and fermented foods

Causes & Risk Factors

  • Impaired migrating motor complex — the wave that sweeps the small intestine clean between meals
  • Post-infectious IBS following food poisoning, which can damage motility signalling
  • Low stomach acid, including from long-term proton pump inhibitor use
  • Structural factors: adhesions from prior surgery, strictures, or an incompetent ileocaecal valve
  • Hypothyroidism, diabetes, and connective tissue disorders that slow gut transit
  • Chronic stress and vagal tone problems that suppress digestive motility

Naturopathic Approach

Naturopathic treatment of SIBO follows a sequence, and skipping steps is why so many people relapse. Diagnosis comes first: a three-hour lactulose or glucose breath test measuring hydrogen and methane identifies whether overgrowth is present and which gas predominates, which in turn determines treatment, since methane-predominant overgrowth behaves differently and responds to different agents than hydrogen-predominant. Botanical medicine is the primary treatment tool — berberine, oregano oil, neem, allicin and similar antimicrobials have evidence comparable to rifaximin in head-to-head work — and Dr. Sanika refers for prescription antibiotics where that is the better option. Clinical nutrition is used as symptom control during treatment rather than as the treatment itself: low-FODMAP and similar approaches reduce fermentable substrate and make people considerably more comfortable, but starving bacteria indefinitely is not a cure and long-term restriction narrows the microbiome in ways that cause their own problems, so the diet is deliberately time-limited and food is reintroduced systematically. The step that determines whether SIBO stays gone is the prevention phase: prokinetic support to restore the migrating motor complex, spacing meals so that the cleaning wave can actually run, addressing low stomach acid, treating hypothyroidism if present, and vagal and stress work where motility is being suppressed by the nervous system. Functional lab testing checks iron, B12 and fat-soluble vitamin status, which are commonly depleted by the malabsorption that overgrowth causes.

Related Modalities

Frequently Asked Questions

Why does my SIBO keep coming back?

Because the overgrowth was treated but the reason for it was not. SIBO is a consequence, not a first cause. If your migrating motor complex is impaired, your stomach acid is low, your thyroid is underactive, or you have adhesions from an old surgery, bacteria will re-accumulate no matter how effective the antimicrobial course was. Relapse rates are high precisely when the prevention phase is skipped. This is why the workup looks for the underlying driver rather than stopping at a positive breath test.

Is a low-FODMAP diet the treatment for SIBO?

No — it is symptom management. Reducing fermentable carbohydrate means less gas and considerably less bloating, which is genuinely valuable while you are being treated. But it suppresses symptoms rather than clearing overgrowth, and staying on it long-term reduces microbial diversity and can make you more reactive over time. It is used as a defined-duration tool alongside antimicrobial treatment, with a structured reintroduction afterwards.

Do I need a breath test, or can we just treat it?

Testing is worth doing. Hydrogen-predominant and methane-predominant overgrowth respond to different antimicrobials, so treating blind means a meaningful chance of choosing the wrong agent. A breath test also gives a baseline to retest against, so you know whether treatment worked rather than guessing from how you feel — which is unreliable, since diet changes made at the same time also improve symptoms.

Can SIBO explain my fatigue and brain fog?

It often contributes. Bacterial overgrowth impairs absorption of iron and vitamin B12, both of which cause fatigue and cognitive symptoms when low, and the inflammatory load from overgrowth has systemic effects. That said, fatigue has many causes, so the workup checks iron studies, B12, thyroid function and other contributors rather than attributing everything to the gut.

References

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Dr. Sanika Kshirsagar

Dr. Sanika Kshirsagar, ND

Doctorate of Naturopathic Medicine (ND)

Bastyr University, Kenmore, WA

Last reviewed:byDr. Sanika Kshirsagar, ND